文章摘要

葡萄糖转运蛋白1在癌症中的表达及其调控

作者: 1陆凯强, 1徐秋蓉, 1谢伟全, 1熊婷, 1黄雪龙, 2周志刚, 1涂剑
1 南华大学药物药理研究所，湖南 衡阳 421001
2 南华大学第一附属医院麻醉科，湖南 衡阳 421001
通讯: 周志刚 Email: zhouzhigang0734@sina.com
涂剑 Email: tujian0734@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2016.09.032
基金: 国家自然科学基金资助项目, 81541163 湖南省自然科学基金资助项目, 2015JJ3101 湖南省教育厅创新平台项目, 15K111 湖南省分子靶标新药研究协同创新中心”培育项目, 2014-405

摘要

作为葡萄糖溶质载体2A家族的成员，葡萄糖转运蛋白1(glucose transporter 1，Glut1)主要负责调控细胞糖转运及糖代谢。研究发现在癌症中其表达量都有明显提高，为癌细胞增殖、侵袭迁移等多种生命活动提供足够的葡萄糖及ATP，与癌症的发生发展存在密切关系。因此，以Glut1为治疗靶标，干扰癌细胞葡萄糖代谢，将为癌症诊断及其治疗提供新的思路。
关键词： 葡萄糖转运蛋白1 癌症 表达调控

Expression and regulation of glucose transporter 1 in cancer

Authors: 1LU Kaiqiang, 1XU Qiurong, 1XIE Weiquan, 1XIONG Ting, 1HUANG Xuelong, 2ZHOU Zhigang, 1TU Jian
1 Institute of Pharmacy and Pharmacology, University of South China, Hengyang Hunan 421001
2 Department of Anesthesiology, the First Affiliated Hospital, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: ZHOU Zhigang Email: zhouzhigang0734@sina.com

DOI: 10.3978/j.issn.2095-6959.2016.09.032

Abstract

Glucose transporter 1 (Glut1) belongs to the glucose solute carrier family 2A, and the regulation of cellular glucose transport and glucose metabolism are the major function of it. The Glut1 provides enough glucose and ATP for the regulation of glucose transport and glucose metabolism for the proliferation, invasion and migration of cancer cells, and the expression of it is significantly increased in tumor cells. Therefore, regarding Glut1 as a therapeutic target might interfere in glucose metabolism of malignant tumor cells and provide a new idea for the diagnosis and treatment of the malignant tumor.

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