文章摘要

miRNAs在慢性阻塞性肺疾病中的研究进展

作者: 1胡亭亭, 2肖祖克
1 南昌大学研究生院医学部，南昌 330006
2 江西省人民医院呼吸内科，南昌 330006
通讯: 肖祖克 Email: xiaozuke@126.com
DOI: 10.3978/j.issn.2095-6959.2016.07.024
基金: 江西省科技计划项目资助, 20151BBG70121

摘要

微小RNAs(microRNAs，miRNAs)是一种非编码小分子单链RNAs，其通过与靶mRNA完全或部分结合，从而在转录后水平调控基因的表达。近年来，诸多研究显示miRNAs与慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)的发生发展密切相关。本文就miRNAs与烟草烟雾、肺气肿、炎症的关系进行综述，并侧重阐述miRNAs参与调控COPD作用机制及其临床应用前景。
关键词： miRNA 烟草烟雾 肺气肿 炎症 慢性阻塞性肺疾病

Progress in the role of miRNAs in chronic obstructive pulmonary disease

Authors: 1HU Tingting, 2XIAO Zuke
1 Medical Department of Graduate School of Nanchang University, Nanchang 330006
2 Department of Respiratory Medicine, Jiangxi Province People’s Hospital, Nanchang 330006, China

CorrespondingAuthor: XIAO Zuke Email: xiaozuke@126.com

DOI: 10.3978/j.issn.2095-6959.2016.07.024

Abstract

miRNAs are small non-coding single-stranded RNAs, which regulate gene expression at posttranscriptional level through completely or partially binding to mRNA targets. Currently, more and more researches have revealed that miRNAs participates in the development of chronic obstructive pulmonary disease (COPD). This review will introduce the relationship between miRNAs and cigarette smoke exposure, emphysema, inflammation. The regulating mechanism and potential clinical application of miRNAs in COPD will be highlighted.

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