Objective: To analyze the effect of Yiqiyangyinhuoxue decoction combined with atorvastatin on statin treatment of blood stasis type early diabetic nephropathy with the deficiency of both Qi and Yin. Methods: A total of 80 cases of blood stasis type early diabetic nephropathy with Qi and Yin deficiency were selected from January 2013 to December 2014 in the hospital, the patients were randomly divided into treatment group and control group, each of 40 cases. The control group was treated with atorvastatin treatment, and the treatment group plus Yiqiyangyinhuoxue decoction treatment on the basis of the control group. Before and after treatment, detected the level of C reactive protein (CRP), glycosylated hemoglobin (HbAlc), and plasma homocysteine (HCY) in venous blood samples of patients; evaluated the effect of the treatment; detected the level of urinary albumin excretion rate (UAER), 24-h urinary protein excretion rate (24hUAE), serum creatinine (Scr), 24-h urinary protein (24hUPQ), urea nitrogen (BUN) in the two groups. Results: After treatment, the level of CRP, HbA1c, HCY, UAER, 24hUAE, SCR, 24hUPQ in the treatment group was lower than that in the control group, the difference was statistically significant (P<0.05); the level of TC, TG, LDL-C in both groups was lower than those before treatment; HDL-C level was higher than that before treatment, and the difference between the two groups was statistically significant (P<0.05). The effective rate in the treatment group was 87.50%, while in the control groups the rate was 65.00%, which was significantly lower than that in the treatment group (P<0.05); comparison of adverse reactions of the two groups has no statistical significance (P>0.05). Conclusion: Yiqiyangyinhuoxue decoction combined with atorvastatin cutting statins has the effects of lipid-lowering and hypoglycemic, enriching yin and nourishing kidney, promoting blood circulation, and further effectively delays the progression of early diabetes with Qi and Yin deficiency and blood stasis.