Objective: To explore the clinical effect of eliminating phlegm nursing in elderly patients, who need to stay in bed for a long time, with cerebral arterial thrombosis complicated with lung infection. Methods: A total of 244 patients were selected and randomly divided into study group and control group, 122 cases in each group. All patients in two groups were treated with routine treatment and nursing, and aerosol inhalation. Sputum expectoration machine were used in eliminating phlegm of control group, while sputum expectoration machine, artificial percussion and clap and postural drainage were used in the research group. Amount of eliminating phlegm, SPO2 before and after eliminating phlegm, and efficacy rate of eliminating phlegm were compared between the two groups. Results: The amount of eliminating phlegm, SPO2 after eliminating phlegm and the efficacy rate of eliminating phlegm of study group were higher than those of the control group, the difference was statistically significant (P<0.05). Conclusion: It can increase the amount of eliminating phlegm by using phlegm sputum expectoration machine combined with artificial percussion and clap and postural drainage; the effect of eliminating phlegm is remarkable. It’s worthy of promotion and application.