妊娠期糖尿病与孕妇血清C-反应蛋白水平相关性研究
| 作者: |
1王丽蕊
1 河北省围场县医院妇产科，河北 围场 068450 |
| 通讯: |
王丽蕊
Email: wanglirui333@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.07.007 |
摘要
目的：探究妊娠期糖尿病与孕妇血清C-反应蛋白水平相关性。方法：选取2014年4月至2015年11月于我院接受孕检的孕妇190例，其中糖尿病孕妇97例，作为本研究实验组；另外93例健康状况良好，作为对照组。记录并比较两组孕妇年龄、平均孕周、孕前体重指数(BMI)；检查并比较其血清C-反应蛋白(CRP)水平、胰岛素抵抗指数、空腹血糖水平、空腹胰岛素水平、孕期体重增长，并对CRP的相关影响因素进行Pearson相关分析以及多元线性回归分析。结果：对照组孕妇平均年龄为(29.13±2.18)岁，平均孕周为(25.36±3.23)周，孕前BMI为(20.27±1.72) kg/m2；实验组孕妇平均年龄为(28.24±1.97)岁，平均孕周(26.13±2.79)周，孕前BMI为(20.32±1.68) kg/m2，对比结果无统计学差异(P>0.05)；对照组空腹血糖含量为(4.62±0.54) mmol/L，实验组为(5.21±0.81) mmol/L，对比结果无统计学意义(P>0.05)；对照组空腹胰岛素水平为(8.93±1.76) mmol/L，实验组为(11.71±4.83) mmol/L，对比结果具有统计学意义(P<0.05)；对照组孕妇血清CRP含量为(2.17±0.76) mg/L，胰岛素抵抗指数为1.76±0.69，孕期体重增长(13.47±2.01) kg，实验组为孕妇血清CRP含量为(4.12±0.73) mg/L，胰岛素抵抗指数为2.57±2.18，孕期体重增长(17.13±5.79) kg，对比结果具有统计学意义(P<0.05)；Pearson分析显示血清CRP水平与胰岛素抵抗指数、孕期体重增长、孕前体重指数、空腹血糖呈正相关关系，其系数分别为0.369、0.319、0.289、0.268，均具有统计学意义(P<0.05)，对CRP的多元线性回归分析，其方程为y(CRP)=0.319X1+0.09X2+0.239X3−3.879，r2=0.259(X1：胰岛素抵抗指数，X2：孕期体重增长，X3：孕前体重指数)。结论：对于妊娠期妇女，血清C-反应蛋白水平超标是引起糖尿病的重要因素之一，但独立影响尚不能被证实，建议临床上在孕期定期检查孕妇血清C-反应蛋白水平，有利于妊娠期糖尿病的有效防治。
关键词：
妊娠期糖尿病
C-相关蛋白
相关性
Relationship between serum C-reactive protein level and gestational diabetes mellitus
CorrespondingAuthor: WANG Lirui Email: wanglirui333@163.com
DOI: 10.3978/j.issn.2095-6959.2016.07.007
Abstract
Objective: To explore the relationship between serum C-reactive protein level and gestational diabetes mellitus. Methods: 190 cases of pregnant women in our hospital were selected between April 2014 and November 2015, including 97 cases of diabetic pregnant women, as the experimental group; the other 93 cases were in good health condition, as the control group. Recorded and compared the age, average gestational time, body mass index (BMI) of two groups pregnant women; checked and compared the serum C-reactive protein (CRP) level, insulin resistance index, fasting blood glucose level, fasting insulin levels, weight gain during pregnancy, and analyzed the related influencing factors on CRP according to Pearson correlation analysis and multiple linear regression analysis. Results: The average age of pregnant women in the control group is (29.13±2.18) years, mean gestational time is (25.36±3.23) weeks, pre-pregnancy BMI is (20.27±1.72) kg/m2; the average age of pregnant women in the experimental group is (28.24±1.97) years, mean gestational age is (26.13±2.79) weeks, pre-pregnancy BMI is (20.32±1.68) kg/m2, there’s no significant difference between experimental group and control group (P>0.05); the fasting blood glucose level of the control group is (4.62±0.54) mmol/L, the experimental group is
(5.21±0.81) mmol/L, there’s no significant difference between experimental group and control group (P>0.05); the fasting insulin levels of control group is (8.93±1.76) mmol/L, the experimental group’s (11.71±4.83) mmol/L,
the comparison results were statistically significant (P<0.05); the maternal serum CRP content of control group is (2.17±0.76) mg/L, insulin resistance index is 1.76±0.69, weight gain during pregnancy is (13.47±2.01) kg, the maternal serum CRP content of the experimental group is (4.12±0.73) mg/L, insulin resistance index is 2.57±2.18, weight gain during pregnancy is (17.13±5.79) kg, the comparison results were statistically significant (P<0.05); Pearson analysis showed that serum CRP levels, insulin resistance index, weight gain during pregnancy, pre-pregnancy body mass index, fasting plasma glucose was positively correlated, the coefficients were as 0.369, 0.319, 0.289, 0.268, it was statistically significant (P<0.05), through the multiple linear regression analysis of CRP, the equation y (CRP) =0.319X1+0.09X2+0.239X3−3.879, r2=0.259 (X1: insulin resistance index, X2: weight gain during pregnancy, X3: pre-pregnancy body mass index). Conclusion: For pregnant women, excessive levels of serum C-reactive protein is an important factor in causing diabetes, but its independent effect cannot be confirmed, it is suggested that the serum levels of C-reactive protein in pregnant women are regularly checked during pregnancy, it’s good for the prevention and treatment of gestational diabetes.
(5.21±0.81) mmol/L, there’s no significant difference between experimental group and control group (P>0.05); the fasting insulin levels of control group is (8.93±1.76) mmol/L, the experimental group’s (11.71±4.83) mmol/L,
the comparison results were statistically significant (P<0.05); the maternal serum CRP content of control group is (2.17±0.76) mg/L, insulin resistance index is 1.76±0.69, weight gain during pregnancy is (13.47±2.01) kg, the maternal serum CRP content of the experimental group is (4.12±0.73) mg/L, insulin resistance index is 2.57±2.18, weight gain during pregnancy is (17.13±5.79) kg, the comparison results were statistically significant (P<0.05); Pearson analysis showed that serum CRP levels, insulin resistance index, weight gain during pregnancy, pre-pregnancy body mass index, fasting plasma glucose was positively correlated, the coefficients were as 0.369, 0.319, 0.289, 0.268, it was statistically significant (P<0.05), through the multiple linear regression analysis of CRP, the equation y (CRP) =0.319X1+0.09X2+0.239X3−3.879, r2=0.259 (X1: insulin resistance index, X2: weight gain during pregnancy, X3: pre-pregnancy body mass index). Conclusion: For pregnant women, excessive levels of serum C-reactive protein is an important factor in causing diabetes, but its independent effect cannot be confirmed, it is suggested that the serum levels of C-reactive protein in pregnant women are regularly checked during pregnancy, it’s good for the prevention and treatment of gestational diabetes.