涎腺腺泡细胞癌临床病理分析并文献复习
| 作者: |
1刘畅,
2许春伟,
2王晶晶,
3张立英
1 中国人民解放军北京军区总医院肿瘤科，北京 100700 2 军事医学科学院附属医院病理科，北京 100071 3 中国人民解放军北京军区总医院病理科，北京 100700 |
| 通讯: |
刘畅
Email: bewilder2007@sina.com 许春伟 Email: xuchunweibbb@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.07.028 |
摘要
目的：探讨涎腺腺泡细胞癌的临床病理学特点及诊断要点。方法：对1例涎腺腺泡细胞癌进行临床资料、病理形态学及免疫组织化学观察，并结合文献对其诊断及鉴别诊断进行探讨。结果：镜下瘤细胞胞体宽大，胞浆嗜碱性呈细颗粒状，核圆形瘤细胞生长呈腺泡状或实性片状生长，部分区域呈乳头状改变，免疫组化显示AE1/AE3(+)、CK8/18(+)、CK7(+)、AAT(+)、S-100(+)。结论：涎腺腺泡细胞癌发病率低，但根据其常见的发病部位及特征性的组织形态，结合免疫组织化学方法，有助于其诊断及鉴别诊断。
关键词：
涎腺腺泡细胞癌
诊断
鉴别诊断
免疫组织化学
Clinicopathologic analyses of salivary gland acinar cell carcinoma and review of the literature
CorrespondingAuthor: LIU Chang Email: bewilder2007@sina.com
DOI: 10.3978/j.issn.2095-6959.2016.07.028
Abstract
Objective: To investigate the clinicopathological features and diagnostic criteria of salivary gland acinar cell carcinoma. Methods: Retrospectively analyzed the features of clinicopathology and immunohistochemistry of a case of salivary gland acinar cell carcinoma, and combined together the review of the literatures. Results: Under light microscope, the tumor cell body was wide, and basophilic cytoplasm was fine granular, nuclear round tumor cell growth was gland bubbly or slice solid growth, area of tumor was the papillary change, this case showed positive immunostaining for AE1/AE3, CK8/18, CK7, AAT and S-100. Conclusion: Salivary gland acinar cell carcinoma has a low incidence, but its frequent position of invasion and typical histology shape, combining together immunohistochemistry methods, will make for diagnosis and differential diagnosis possible.