Objective: To investigate the clinical features and treatment program of giant cell tumor of limbs with pathological fractures. Methods: A total of 86 cases patients with giant cell tumor of limbs and pathological fractures were treated in our hospital from April 2007 to April 2013 were selected. The main clinical features and reasonable treatment method of this disease were analyzed. Results: In the 86 patients with giant cell tumor of limbs and pathological fractures, age mainly in the 30 to 39 years old, the most common site is the distal femur. Through the clinical surgery, the presence of intracapsular curettage in 5 cases of patients with recurrent, large pieces of tumor resection surgery in patients with no recurrence of the situation, but there are 17 patients had postoperative prosthesis-related complications. Tumor resection prosthesis replacement patients MSTS score was (21.7±4.2) points, other reconstruction patients MSTS score was (22.3±4.3) points. Conclusion: Pathologic fracture limb long bone in patients with giant cell tumor of limbs is common in distal femur. The large pieces of tumor resection surgery and intracapsular curettage are the main treatment.