染料木素心血管保护作用及机制研究
| 作者: |
1李冬花,
1黄红林
1 南华大学药物药理研究所，湖南 衡阳 421001 |
| 通讯: |
李冬花
Email: 798949591@qq.com 黄红林 Email: 516526281@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.08.025 |
| 基金: | 湖南省中医药管理局重点项目, NO.201211 |
摘要
染料木素(genistein，Gen)是一种化学结构与雌激素相似，主要从大豆、三叶草、染料木等豆科植物中提取出来的活性成分，被称为植物雌激素。大量研究表明Gen可以通过调节脂类代谢、抗氧化、血管保护及抗炎等机制，从而发挥防治动脉粥样硬化(atherosclerosis，AS)、心肌保护、抗心律失常、调节血压等心血管的保护作用。本文就Gen的心血管保护作用机制的研究进展及展望作一综述。
关键词：
染料木素
心血管保护
作用机制
Research progress on cardiovascular protection effect and its mechanisms of genistein
CorrespondingAuthor: LI Donghua Email: 798949591@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.08.025
Abstract
Genistein (Gen) is called phytoestrogens with a chemical structure similar to estrogen, which was mainly extracted by the leguminous plants such as soybeans, clover, and dye wood active ingredient. Numerous studied have demonstrated that genistein plays protective effects against arteriosclerosis, myocardial protection, arrhythmia and regulate blood pressure, via regulating lipid, resistance to oxidation and inflammatory, protecting blood vessels. Therefore, the purpose of this article is to review the function and mechanisms of genistein in cardiovascular effects.