肺原发性脑膜瘤1例并文献复习
| 作者: |
1张立英,
1皋岚湘,
2于光宇,
3许春伟,
1丁华野
1 北京军区总医院病理科，北京 100700 2 盘锦市中心医院病理科，辽宁 盘锦 124010 3 军事医学科学院附属医院病理科，北京 100071 |
| 通讯: |
张立英
Email: lyzhang1@126.com 皋岚湘 Email: gaolx51@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.05.038 |
摘要
目的：探讨肺原发性脑膜瘤的临床病理特征、诊断和鉴别诊断、治疗及预后。 方法：回顾性分析1例肺原发性脑膜瘤患者的临床资料、组织病理形态、免疫组织化学染色、治疗及随访结果，并回顾相关文献。结果：光镜下肿瘤细胞呈短梭形，细胞呈漩涡状排列，细胞异型性不明显，未见明确核分裂象。免疫组织化学染色结果显示肿瘤细胞胞浆AE1/AE3、CK8/18灶状(+)、EMA(+)， S100、SMA、TTF-1、CD34、CD31、PR、ALK、Syn均(–)，Ki-67阳性率约1%。组织学和免疫组织化学染色结果均支持良性脑膜瘤的诊断。结论：肺原发性脑膜瘤十分少见，掌握其临床病理特征对该病的诊断、鉴别诊断、治疗及预后具有重要意义。
关键词：
脑膜瘤
肺
原发
病理诊断
Primary pulmonary meningioma: a case report and review of the literature
CorrespondingAuthor: Zhang Liying Email: lyzhang1@126.com
DOI: 10.3978/j.issn.2095-6959.2015.05.038
Abstract
Objective: To investigate the clinical and pathological features, diagnosis and differential diagnosis, treatment and prognosis of primary pulmonary meningioma. Methods: Retrospective analysis of the clinical data was conducted in one case of primary pulmonary meningioma, and the histopathological morphology, immunohistochemistry staining, treatment and follow-up data, and related literatures. Results: Under light microscope, it disclosed a tumor compressing the adjacent lung parenchyma. At higher magnification the lesion was composed of nests of polygonal to spindle-shaped cells arranged in fascicles or whorls. There was no pleomorphism, mitotic figures were also absent. Immunohistochemically, revealed spottily positivity for AE1/AE3 , CK8/18, and a strong positivity for EMA. S100, SMA, TTF-1, CD34, CD31, PR, ALK and Syn were all negative. Ki-67-positive rate was about 1%. The histological and immunohistochemical features strongly suggested the diagnosis of benign meningioma. Conclusion: The incidence of primary pulmonary meningioma is very low, therefore, grasp the clinical and pathological features of the disease, will play an important role in the diagnosis, differential diagnosis, treatment and prognosis of it.