Most patients manifested high metabolic process, energy consumption, difficulty in feeding after severe traumatic brain injury or brain surgery. Early enteral nutrition (EN) is necessary for those patients due to the high risk and complication of long-term intravenous nutrition. Individualized nutritional program must be established on the basis of the evaluation of patients’ nutritional requirements, the feasible way and nutrient composition before EN support. Complications should be detected early and treated timely because EN also has certain risks such as diarrhea, constipation, infectious disease caused by aspiration and obstruction symptoms caused by blockage or position change of input tube. In short, individualized early enteral nutrition program can make benefits to the postoperative patient, so we should pay great attention to its clinical application in neurosurgery.