Objective: To explore the application of comprehensive nursing postoperative nursing of severe traumatic brain injury patients. Methods: A total of 60 cases of severe traumatic brain injury patients were divided into the observation group and the control group by the random number table, the control group was given routine nursing in peri-operation period, the observation group was given the comprehensive nursing after operation, and the two groups were compared of complications, vital signs, the time of hospitalization and nursing satisfaction. Results: SOFA, APACHE II score after nursing in the observation group was lower than that in the control group, GCS was higher than that in the control group, there were statistically significant (P<0.05). The complications in the observation group were less than that in the control group, the anxiety score was lower than that in the control group, in ICU time, the hospitalization time was shorter than that in the control group, nursing satisfaction was higher than that in the control group, there were statistically significant (P<0.05). Conclusion: The comprehensive nursing can reduce postoperative complications of severe traumatic brain operation patients, improve the prognosis.