肿瘤相关胰蛋白酶抑制剂的研究概况
| 作者: |
1王龙圣,
1郑军华
1 同济大学附属上海第十人民医院，上海 200072 |
| 通讯: |
王龙圣
Email: wls0534@163.com 郑军华 Email: zhengjh0471@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.04.015 |
摘要
肿瘤相关胰蛋白酶抑制剂(tumor-associated trypsin inhibitor，TATI)又被称为胰腺分泌胰蛋白 酶抑制剂(pancreatic secretory trypsin inhibitor，PSTI)或丝氨酸蛋白酶抑制因子Kazal type 1型 (SPINK1)，是一种由56个氨基酸残基组成的分泌性多肽，主要作用是抑制胰蛋白酶等多种丝氨酸 蛋白酶活性。除此之外，还具有一些其他作用，如类生长因子作用、拮抗细胞杀伤作用等。TATI 在肿瘤中可以作为一种生物标志物。本文将对现阶段关于TATI在肿瘤中作用的相关热点研究进行 综述。
关键词：
肿瘤相关胰蛋白酶抑制剂
肿瘤
生物标志物
Advances of TATI and in tumors
CorrespondingAuthor: WANG Longsheng Email: wls0534@163.com
DOI: 10.3978/j.issn.2095-6959.2015.04.015
Abstract
Tumor-associated trypsin inhibitor (TATI), also known as the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor Kazal type 1 (SPINK1), encodes a 56 amino acid secreted peptide. In addition to being a protease inhibitor, it may also act as an autocrine growth factor or an antagonism of apoptosis, and so on. In tumor, TATI acts as a biomarker. In this review, we will summarize the current understanding of TATI and its role in tumors.