血压正常的2型糖尿病患者24 h动态血压与血清 胱抑素C相关性研究
| 作者: |
1沈俊,
1杨田,
1高学文,
1刘星
1 宜昌市夷陵医院心内科，湖北 宜昌 443100 |
| 通讯: |
杨田
Email: hxlayt@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.02.014 |
摘要
目的 探讨血压正常的2型糖尿病(type 2 diabetes mellitus，T2DM)患者24h动态血压与血清胱抑素C( cystatin C，Cys C)的相关性。方法 入选符合纳入标准的T2DM患者80例，据血清Cys C水平将患者分为正常组（Cys C<1.25mg/L,共42例）和异常组（Cys C>1.25mg/L,共40例），同时所有患者均进行24 h动态血压监测(ambulatory blood pressure monitoring，ABPM)。结果 两组患者在24h收缩压（24hSBP） 、白天收缩压（dSBP）、夜间收缩压（nSBP）、24h平均动脉压(24hMAP)、白天平均动脉压(dMAP)、夜间平均动脉压(nMAP)、夜间收缩压最低均值、起床前2h收缩压均值及起床后2h收缩压均值比较，差异均有统计学意义（P<0.05）；而在24hDBP、dDBP、nDBP、夜间舒张压最低均值、起床前2h舒张压均值及起床后2h舒张压均值比较，差异均无统计学意义（P>0.05）。对Cys C作Pearson 相关分析显示，Cys C与24hSBP、dSBP、nSBP、24hMAP、dMAP、nMAP、夜间收缩压最低均值、起床前2h收缩压均值及起床后2h收缩压均值呈正相关(P<0.05)，但与24hDBP、dDBP、nDBP、夜间舒张压最低均值、起床前2h舒张压均值及起床后2h舒张压均值无相关(P>0.05)。结论 血压正常的T2DM患者，早期肾功能损害与收缩压均值及MAP呈正相关，而与舒张压均值无相关。
关键词：
2型糖尿病
胱抑素C
动态血压
The relationship between 24 h ambulatory blood pressure and serum cystatin in type 2 diabetes mellitus with normal blood pressure
CorrespondingAuthor: YANG Tian Email: hxlayt@163.com
DOI: 10.3978/j.issn.2095-6959.2015.02.014
Abstract
Objective TO investigate the relationship of between 24 hours ambulatory blood pressure and serum cystatin in type 2 diabetes mellitus with normal blood pressure. Methods A total of 80 patients with T2DM met the inclusion criteria were enrolled．These 80 cases were divided into normal control group (Cys C<1.25mg/L, a total of 42 cases) and the exception group (Cys C>1.25mg/L, a total of 40 cases) according to Serum Cystatin c levels. Results Comparison between two groups in 24hSBP, dSBP, nSBP, 24hMAP, dMAP,nMAP, minimum mean systolic blood pressure at night, 2hSBP before getting up ,2hSBP after getting up ,were significant differences（P<0.05）.Comparison between two groups in 24hDBP、dDBP、nDBP,
minimum mean diastolic blood pressure at night, 2hDBP before getting up ,2hDBP after getting
up ,were not significant differences（P>0.05）. Pearson correlation analysis to showed that 24hSBP, dSBP, nSBP, 24hMAP, dMAP,nMAP, minimum mean systolic blood pressure at night, 2hSBP before getting up ,2hSBP after getting up were positively correlated with cystatin C(P<0.05),but there was no close correlation with 24hDBP、dDBP、nDBP, minimum mean diastolic blood pressure at night, 2hDBP before getting up ,2hDBP after getting up (P>0.05).Conclusion Early renal impairment with type 2 diabetes mellitus with normal blood pressure was positively correlated with systolic blood pressure and mean arterial pressure, and was not correlated with diastolic blood pressure .
minimum mean diastolic blood pressure at night, 2hDBP before getting up ,2hDBP after getting
up ,were not significant differences（P>0.05）. Pearson correlation analysis to showed that 24hSBP, dSBP, nSBP, 24hMAP, dMAP,nMAP, minimum mean systolic blood pressure at night, 2hSBP before getting up ,2hSBP after getting up were positively correlated with cystatin C(P<0.05),but there was no close correlation with 24hDBP、dDBP、nDBP, minimum mean diastolic blood pressure at night, 2hDBP before getting up ,2hDBP after getting up (P>0.05).Conclusion Early renal impairment with type 2 diabetes mellitus with normal blood pressure was positively correlated with systolic blood pressure and mean arterial pressure, and was not correlated with diastolic blood pressure .