Each gene rearrangement phenomenon is experienced in the early lymphocyte a normal process, because the body of each lymphocyte gene rearrangement is unique, so that each has a unique rearrangement of lymphocytes form. Should the body lose control of the cell of a gene rearrangement in certain tumorigenic effect factors, the cells will be no control monoclonal proliferation, ultimately leading to the formation of lymphoma. So lymphoma has a monoclonal rearrangement. Therefore, by polymerase chain reaction technology for T cell receptor (TCR) gene rearrangement analysis, especially when conventional HE morphological and immunohistochemical results could not be confirmed, it is particularly important. In this paper, the role of T cells in the pathological diagnosis of lymphoma in a review of its work.