幽门螺杆菌感染和脉搏波传导速度对冠心病的预测价值
| 作者: |
1王军,
1李世敬,
1陈浩,
2王德昭
1 北京市门头沟区医院，北京 102300 2 首都医科大学附属北京天坛医院，北京 100050 |
| 通讯: |
王德昭
Email: dezhao.w@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.05.023 |
摘要
目的：探讨幽门螺杆菌(Helicobacter pylori，Hp)感染和肱-踝脉搏波传导速度(brachial-ankle pulse wave velocity，baPWV)对冠心病(coronary artery disease，CAD)的预测价值。方法：选择北京市门 头沟区医院心内科2010年1月~2012年12月住院治疗并且行冠状动脉造影(coronary angiography， CAG)检查的患者472例。根据CAG结果将入选病例分为CAD组(n=225例)和对照组(n=247例)。 所有患者在CAG前空腹行血液生化检查、C13呼气试验和脉搏波传导速度测量。比较两组的各 项指标，使用Logistic多因素回归分析评价CAD的危险因素。结果：两组患者高脂血症病史、糖 尿病史、吸烟、血糖、低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL-c)、Hp、 同型半胱氨酸(homocysteine，HCY)、心肌型肌酸激酶同工酶(MB isoenzyme of creatine kinases， CK-MB)峰值和baPWV比较均有统计学差异；Logistic多因素回归分析显示：吸烟、糖尿病病史、 Hp感染(OR=4.176，95% CI: 2.631~6.628，P<0.001)、baPWV≥1 700 cm/s(OR=3.489，95% CI: 2.120~5.741，P<0.001)和高敏C反应蛋白(high-sensitivity c-reactive protein，hs-CRP)≥3.00 mg/L (OR=2.189，95% CI: 1.280~3.743，P=0.004)是CAD的危险因素。结论：Hp感染和baPWV≥1 700 cm/s 对CAD有一定的预测价值。
关键词：
冠心病
幽门螺杆菌
肱踝脉搏波传导速度
预测价值
Predictors of coronary artery disease: Helicobacter pylori infection and brachial-ankle pulse wave velocity
CorrespondingAuthor: WANG Dezhao Email: dezhao.w@126.com
DOI: 10.3978/j.issn.2095-6959.2014.05.023
Abstract
Objective: To explore the relationship between Helicobacter pylori (Hp) infection, brachial-ankle pulse wave velocity (baPWV) and coronary artery disease (CAD) and Hp infection and baPWV value for the forecast of CAD. Methods: A total of 472 patients with coronary angiography (CAG) were enrolled. The patients were divided into control group (n=247) and CAD group (n=225) according to the result of CAG. All patients took the examination of fasting blood biochemical, 13C urea breath test and baPWV. We analyzed the difference of these factors in all groups and explored the correlation between Hp infection or baPWV and CAD using logistic regression analysis. Results: There was significant difference in hyperlipidemia history, diabetes history, smoking, blood sugar, low density lipoprotein cholesterol (LDL-c), Hp infection, homocysteine (HCY), MB isoenzyme of creatine kinases (CK-MB) and baPWV between two groups. In Logistic regression model, smoke, diabetes history, Hp infection (OR=4.176, 95% CI: 2.631~6.628, P<0.001), baPWV≥1 700 cm/s (OR=3.489, 95% CI: 2.120~5.741, P<0.001) and high-sensitivity c-reactive protein (hsCRP) ≥3.00 mg/L (OR=2.189, 95% CI: 1.280~3.743, P=0.004) were independent predictors for CAD. Conclusion: Hp infection and baPWV for CAD have predictive value.