MicroRNA 在粒细胞增殖和分化中的调控作用
| 作者: |
1张熠,
1杨靖,
1文格波
1 南华大学附属第一医院内分泌科，湖南 衡阳 421001 |
| 通讯: |
文格波
Email: gb_wen@aliyun.com |
| 基金: | 国家自然科学基金(81100560) |
摘要
微小RNA(microRNA，miRNA）是高度保守的非蛋白编码的RNA，可调节基因的表达。研究表明骨髓原始及幼稚造血细胞的增殖与分化异常是很多血液系统疾病的骨髓学特点；而miRNA参与骨髓造血调控，并且与血液系统疾病的发生存在密切的关系。本文着重综述miRNA对粒细胞增殖和分化的调控。
关键词：
miRNA；粒细胞；增殖；分化
Effect of microRNA on the proliferation and differentiation of granulocytes
CorrespondingAuthor: WEN Gebo Email: gb_wen@aliyun.com
Abstract
MicroRNA (miRNA) is a kind of conserved, non-protein-coding RNA, which can regulate the expression of target genes. MiRNA plays a complicated regulatory role in the cellular processes of proliferation and differentiation. Many studies have shown that the abnormal proliferation and differentiation of immature hematopoietic cells are the bone marrow characters of blood system diseases. MiRNA is involved in bone marrow hematopoiesis and closely related to the development of hematological diseases. We summarized the role of miRNA in the proliferation and differentiation of granulocytes in this article.