Objective: To explore the clinicopathological and differentiated features of squamo-transitional carcinoma(STCC). Methods: Five patients with squamo-transitional carcinoma were reviewed according to the classification of uterine tumors provided by WHO in 2003. Results: The median age of 5 patients was 45 years old. The patients mainly presented abnormal hemorrhage in vagina, uterine cervix hypertrophy, polypoid or cauliflower-like neoplasia. Cytologically, it displayed differentiation of migration, squamous cell or glandular cell without obvious koilocytotic cell. Histologically, it showed papillary squamo-transitional stratified epithelium with fibrous and vessel stroma. Two patients did not display invasion while 2 or 1 showed papillal stroma or wall of cervix invasion. Immunohistochemically, the tumor cells showed positive for P16, CK19, CK5/6, and CK 7. Only one was positive for CK 20 and 4 patients were HPV positive. Conclusion: STCC is an uncommon type of papillary squamous cell carcinoma with squamo-transitional and certain gland features, and it is related to high risk of HPV infection with features of invasion, recurrence, and metastasis. STCC should be differentiated from other corpora mammillaria tumors of cervix.