趋化因子受体XCR1及其配体研究进展
| 作者: |
1陈淑华,
2卢元珺,
1肖献忠
1 中南大学湘雅医学院病理生理教研室,长沙 410078 2 中南大学生物科学与技术学院生化教研室,长沙 410013 |
| 通讯: |
肖献忠
Email: xianzhongxiao@xysm.net |
| DOI: | 10.3978/j.issn.2095-6959.2013.01.010 |
| 基金: | 国家自然科学基金(81071594) |
摘要
XCR1[chemokine (C motif) receptor 1]是C趋化因子受体家族的唯一成员。最近发现XCR1与其配体的相互作用对树突细胞介导的细胞毒性免疫反应和胸腺的阴性选择发挥重要作用。XCR1和其配体表达异常与过敏性哮喘和风湿性关节炎等自身免疫性疾病以及肿瘤的恶变密切相关。
关键词：
趋化因子
C趋化因子受体1
C趋化因子受体1配体
趋化作用
免疫反应
Progress in the research on XCR 1 and its ligand
CorrespondingAuthor: XIAO Xianzhong Email: xianzhongxiao@xysm.net
DOI: 10.3978/j.issn.2095-6959.2013.01.010
Abstract
XCR1 [chemokine (C motif) receptor 1] is the only member of chemokine C receptor family. Recently, some studies showed that the interaction between XCR1 and its ligand play an important role in dendritic cell-mediated cytotoxic immune response and thymic negative selection. The abnormal expression of XCR1 and its ligand is closely related to the autoimmune diseases such as allergic asthma, rheumatoid arthritis and malignant transformation of tumors.