光动力疗法治疗非小细胞肺癌
| 作者: |
1B Simone II Charles,
2S Friedberg Joseph,
3Glatstein Eli,
4P Stevenson James,
5H Sterman Daniel,
1M Hahn Stephen,
1A Cengel Keith
1 Department of Radiation Oncology,Allergy and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, USA 2 Department of Surgery, Division of Thoracic Surgery;Allergy and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, USA 3 Department of Radiation Oncology;Allergy and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, USA 4 Department of Medicine, Division of Medical Oncology, Allergy and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, USA 5 Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, USA |
| 通讯: |
B Simone II Charles
Email: charles.simone@uphs.upenn.edu |
| DOI: | 10.3978/j.issn.2095-6959.2013.03.001 |
| 基金: | 国立卫生研究院、国家癌症研究所基金, P01 87971 |
摘要
光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌，光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法，光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者，光动力治疗可以作为综合根治疗法的一部分，用于减轻阻塞性支气管内病变，增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述，提出了光动力疗法应用的治疗建议并进行了总结。
关键词：
光动力疗法；肺癌；支气管内；姑息疗法；非小细胞肺癌
Photodynamic therapy for the treatment of non-small cell lung cancer
CorrespondingAuthor: CHARLES BSimoneII Email: charles.simone@uphs.upenn.edu
DOI: 10.3978/j.issn.2095-6959.2013.03.001
Abstract
Photodynamic therapy is increasingly being utilized to treat thoracic malignancies. For patients with early-stage non-small cell lung cancer, photodynamic therapy is primarily employed as an endobronchial therapy to definitely treat endobronchial, roentgenographically occult, or synchronous primary carcinomas. As definitive monotherapy, photodynamic therapy is most effective in treating bronchoscopically visible lung cancers ≤1 cm with no extracartilaginous invasion. For patients with advanced-stage non-small cell lung cancer, photodynamic therapy can be used to palliate obstructing endobronchial lesions, as a component of definitive multi-modality therapy, or to increase operability or reduce the extent of operation required. A review of the available medical literature detailing all published studies utilizing photodynamic therapy to treat at least 10 patients with non-small cell lung cancer is performed, and treatment recommendations and summaries for photodynamic therapy applications are described.