文章摘要

miR-7与胃癌的研究进展

作者: 1邓玲, 1朱欢, 1伍尤华, 1,2苏琦
1 南华大学附属第一医院肿瘤科，湖南省胃癌研究中心，衡阳 湖南 421001
2 南华大学肿瘤研究所，衡阳 湖南 421001
通讯: 苏琦 Email: suqi1945@163.com
DOI: 10.3978/j.issn.2095-6959.2016.03.020
基金: 国家自然科学基金, 81374013 湖南省卫计委科研课题, A2015-2

摘要

近年来microRNA(miRNA)领域已成为研究热点。miR-7是其中重要的成员，在多种肿瘤细胞中表达下调，充当抑癌基因的角色。目前研究发现，miR-7在胃癌中存在多种信号通路调控不同的靶基因抑制胃癌的发生与发展。miR-7可能成为胃癌诊断、治疗和预后的标志物及潜在生物治疗靶分子。本文就miR-7与胃癌的发生发展、相关靶基因和治疗方面的研究进展作一综述。
关键词： miR-7 胃癌 进展 靶基因 治疗

Research progress of miR-7 in gastric cancer

Authors: 1DENG Ling, 1ZHU Huan, 1WU Youhua, 1,2SU Qi
1 Department ot Oncology, First Affiliated Hospital, Center for Gastric Cancer Research of Hunan Province, University of South China, Hengyang Hunan 421001
2 Cancer Research Institute, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: SU Qi Email: suqi1945@163.com

DOI: 10.3978/j.issn.2095-6959.2016.03.020

Abstract

In recent years, microRNA (miRNA) has become a hot topic. miR-7 is one of the important members of miRNA. It downregulates in a variety of tumor cells, acts as suppressor genes. Some current studies has reported that miR-7 can regulate target genes though many different signaling pathways, thus to inhibit the occurrence and development of gastric cancer. miR-7 is likely to be the biological markers of diagnosis, treatment and prognosis, and potential therapeutic target in gastric cancer. The relationship of miR-7 and the development of gastric cancer, relevant target genes and progress of treatment are reviewed in this paper.

文章选项

下载引文

分享