循环肿瘤细胞的检测方法
| 作者: |
1Pantel Klaus,
2Alix-Panabières Catherine
1 Department of Tumour Biology, Centre of Experimental Medicine, University Cancer Center Hamburg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany 2 University Medical Centre, University Montpellier 1, Saint-Eloi Hospital, Institute of Research in Biotherapy, Laboratory of Rare Human Circulating Cells, Montpellier, France; University Medical Centre, Laboratory of Cell and Hormonal Biology, Arnaud de Villeneuve Hospital, Montpellier, France; University Institute of Clinical Research UM1-EA2415-Epidemiology, Biostatistics & Public Health, France |
| 通讯: |
Alix-Panabières Catherine
Email: c-panabieres@chu-montpellier.fr |
摘要
在原发上皮肿瘤形成和生长的早期，肿瘤细胞便可以通过血流播散到远处器官。这些循环肿瘤细胞(circulating tumor cells，CTCs)可以通过不同技术进行富集和检测，其分析被认为是对癌症患者的实时“液体活检”。这种活检能对CTCs特异性亚群进行表征，且有可能为癌症的检测和控制带来革命性的转变。本篇作者将着重讨论当前用于CTCs富集和检测的策略。
关键词：
循环肿瘤细胞
Detection methods of circulating tumor cells
CorrespondingAuthor: Catherine Alix-Panabières Email: c-panabieres@chu-montpellier.fr
Abstract
Early during the formation and growth of a primary epithelial tumor, cells disseminate through the bloodstream to distant organs. These circulating tumor cells (CTCs) can be enriched and detected via different technologies and CTC analyses are considered as a real-time “liquid biopsy” in cancer patients. This biopsy allows the characterization of specific sub-populations of CTCs and may revolutionize cancer detection and management. This editorial highlights the current strategies used for enrichment and detection of CTCs.