Objective: To study the clinical effect of non-steroidal anti-inflammatory drugs in patients with phacoemulsification cataract. Methods: 118 cases patients from January 2015 to December 2015 in our hospital with cataract phacoemulsification were studied. According to a random number table method, they were randomly divided into observation group and control group. Before and after the cataract phacoemulsification procedure, the observation group used the pranoprofen eye drops for adjuvant therapy, while the control group only received surgery and routine postoperative treatment. After surgery, the survey analyzed the incidence of macular edema, the degree of vision correction, and macular thickness of patients. Results: The incidence of postoperative macular edema in the observation group was significantly lower than that in the control group, the differences between the two groups were statistically significant (P<0.05). Compared the macular thickness and degree of vision correction of two groups after surgery, it was found that the degree of vision correction in the observation group was significantly higher than that in the control group, macular thickness was significantly lower than that in the control group, the difference of the two groups were statistically significant (P<0.05). Conclusion: Nonsteroidal anti-inflammatory drugs have a good effect for the prevention of postoperative macular edema, it is worthy of clinical application.