特异性促炎症消退介质在围手术期神经认知障碍中的研究进展
| 作者: |
1程杨,
1刘坤,
1王燕,
1杨艺
1 南华大学附属第二医院麻醉科，湖南 衡阳 421001 |
| 通讯: |
杨艺
Email: yangyi@usc.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2023.221460 |
| 基金: | 湖南省自然科学基金(2022JJ40390)；湖南省卫生健康委员会课题(202217014497)。 |
摘要
围手术期神经认知障碍(perioperative neurocognitive disorders，PND)是老年患者术后常见的并发症，包括谵妄和术后长期记忆障碍。PND可导致患者住院时间延迟长，病死率增高，预后较差。炎症是PND的重要病理机制，炎症不能及时消退与认知功能障碍密切相关。目前认为炎症消退与炎症发生一样，是主动程序性过程，其主要由多不饱和脂肪酸衍生的特异性促炎症消退介质(specialized pro-resolving mediators，SPMs)介导。SPMs可通过减少炎症细胞浸润，调节小胶质细胞表型及星形胶质细胞活性等方式减轻围手术期中枢神经系统炎症，有望为PND的治疗提供新的策略。
关键词：
特异性促炎症消退介质；围手术期神经认知障碍；炎症消退
Research progress of specialized pro-resolving mediators on perioperative neurocognitive disorders
CorrespondingAuthor: YANG Yi Email: yangyi@usc.edu.cn
DOI: 10.3978/j.issn.2095-6959.2023.221460
Foundation: This work was supported by the Natural Science Foundation of Hunan Province (2022JJ40390), and the Project of Hunan Provincial Health Commission (202217014497), China.
Abstract
Perioperative neurocognitive disorders (PND) are the common postoperative complications in the elderly patients, including delirium and postoperative long-term memory impairment. PND can lead to prolonged hospital stay, increased mortality, and poor prognosis. Inflammation is an important pathological mechanism of perioperative neurocognitive impairment, and the timely resolution of inflammation is closely related to cognitive dysfunction. It is currently believed that resolution of inflammatory response is an active procedural process, which is mainly mediated by polyunsaturated fatty acid-derived specialized pro-resolving mediators (SPMs). SPMs can reduce perioperative central nervous system inflammation by ameliorating infiltration of inflammatory cells, modulating microglia phenotype and astrocyte activity, which is expected to provide a new strategy for the treatment of PND.
Keywords：
specialized pro-resolving mediators; perioperative neurocognitive disorders; inflammation resolving