双向调节蛋白与肿瘤的相关性研究进展
| 作者: |
1,1吴焕文,
1梁智勇
1 中国医学科学院，北京协和医学院，北京协和医院病理科，北京 100730 |
| 通讯: |
梁智勇
Email: liangzhiyong1220@yahoo.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.01.013 |
| 基金: | 国家自然科学基金项目资助, 31471366 |
摘要
双向调节蛋白(amphiregulin，AREG)参与机体生理性发育及肿瘤病理性演进过程，特别是在肿瘤细胞的增殖、凋亡、迁移、侵袭等方面有着重要的调控作用。越来越多的研究结果表明，AREG的表达与肿瘤病人的预后及药物疗效预测相关。本文就AREG的结构、功能及在肿瘤发生发展中的相关研究作一综述。
关键词：
双向调节蛋白
表皮生长因子受体
肿瘤
The role of amphiregulin in human cancer
CorrespondingAuthor: LIANG Zhiyong Email: liangzhiyong1220@yahoo.com
DOI: 10.3978/j.issn.2095-6959.2016.01.013
Abstract
Amphiregulin (AREG) is involved in the process of physiological development and tumor pathological evolution, especially plays an important regulatory role on tumor cells proliferation, apoptosis, migration and invasion. An increasing number of studies showed that the expression of AREG is associated with the prognosis of cancer patients and drug curative effect prediction. In this paper, we reviewed the structure, function and the various roles of AREG and in tumorigenesis.