文章摘要

线粒体功能障碍与阿尔茨海默病关系的研究进展

作者: 1曹玉成, 1宋炜熙, 2王哲
1 湖南中医药大学中西医结合学院，长沙 410208
2 中南大学湘雅二医院中西医结合科，长沙 410011
通讯: 宋炜熙 Email: 546202590@qq.com
王哲 Email: ericwangzhe@163.com
DOI: 10.3978/j.issn.2095-6959.2016.03.018
基金: 国家自然科学基金资助项目, 81373705 湖南省自然科学基金资助项目, 13JJ3030

摘要

阿尔茨海默病是老年痴呆症中最常见的类型，其发病机制十分复杂。线粒体是动态细胞器，参与能量代谢、氧化应激，细胞凋亡等调节过程。β淀粉样蛋白、Tau及氧化应激均能够导致线粒体功能损伤，引起线粒体功能障碍，并因此造成突触受损，神经细胞凋亡，促进阿尔茨海默病程的进展。
关键词： 线粒体 阿尔茨海默病 氧化应激 β淀粉样蛋白 Tau

Research progress of the relationship between mitochondrial dysfunction and Alzheimer’s disease

Authors: 1CAO Yucheng, 1SONG Weixi, 2WANG Zhe
1 School of the Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208;
2 epartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital of Central South University, Changsha 410011, China

CorrespondingAuthor: SONG Weixi Email: 546202590@qq.com

DOI: 10.3978/j.issn.2095-6959.2016.03.018

Abstract

Alzheimer’s disease is the most common type of dementia, and its pathogenesis is very complex. Mitochondria are dynamic organelles that participate in the regulation of energy metabolism, oxidative stress, cell apoptosis and so on. Beta amyloid protein, Tau and oxidative stress can lead to mitochondrial dysfunction, which can result in synaptic damage, nerve cell apoptosis and promote the progress of Alzheimer’s disease

文章选项

下载引文

分享