Objective: To explore the construction and intervention strategies of exercise safety early warning system for patients with intraspinal tumors. Methods: A total of 140 patients with intraspinal tumors who were admitted to the Drum Tower Hospital Affiliated to Nanjing University School of Medicine from January 2021 to January 2022 were selected and randomly divided into a control group and a research group, with 70 cases in each group. The control group received routine postoperative intervention, while the research group constructed a postoperative sports safety management system and implemented interventions based on the crisis management model. The degree of postoperative pain, postoperative recovery, changes in negative emotions, dyskinesia, postoperative neurological recovery, and postoperative complications before and after the surgery were compared between the 2 groups. Results: The pain scores of the research group at 12, 24, 48, and 72 h after the operation were lower than those of the control group (all P<0.05); the postoperative ambulation time and postoperative hospital stay in the research group were shorter than those in the control group (both P<0.05); the HAMA and HAMD scores in the 2 groups were significantly decreased 3 months after the operation, and the research group were lower than those in the control group (both P<0.05); the excellent and good rate of neurological function recovery in the research group was higher than that in the control group (P<0.05); the total postoperative complication rate in the research group was 7.14% (5/70), which was lower than that in the control group (P<0.05). Conclusion: Constructing a postoperative exercise safety management system and implementing interventions for patients with intraspinal tumors can not only reduce the degree of pain, reduce the occurrence of complications, but also promote postoperative recovery and relieve patients' anxiety, depression and kinesiophobia.