文章摘要

P53、ATRX蛋白表达评估小儿神经母细胞瘤预后的价值

作者: 1陆洁婷, 2符策君, 1张京
1 海南省妇女儿童医学中心儿童普通外科肿瘤外科，海口 570311
2 海南省人民医院小儿外科，海口 570311
通讯: 张京 Email: guaren_luo1@sina.com
DOI: 10.3978/j.issn.2095-6959.2022.10.004
基金: 海南省卫生健康行业科研项目(20A200259)；海南省临床医学中心建设项目。

摘要

目的：探究应用P53、α-地中海贫血/精神发育迟滞综合征X染色体相关基因(alpha-thalassemia/mental retardation syndrome X-linked，ATRX)蛋白表达评估小儿神经母细胞瘤(neuroblastoma，NB)预后的价值。方法：选择2018年7月至2020年7月海南省妇女儿童医学中心收治的68例NB患儿以及因为肾盂积水就诊的33例患儿作为研究对象，分别为研究组与对照组，应用免疫组织化学法测定患儿病灶组织P53、ATRX蛋白表达情况，收集研究组患儿各项资料，分析研究组患儿P53、ATRX蛋白表达情况与各项资料之间的关系；随访评估NB患儿预后情况，分析P53、ATRX蛋白表达及其他资料与NB患儿预后之间的关系。结果：研究组患儿P53与ATRX表达阳性率均显著高于对照组(均P<0.05)；患儿P53、ATRX表达阳性与患儿临床分期、危险程度、Shimada病理分类、是否存在骨髓浸润、病灶病理诊断、分化程度有关(P<0.05)；多元logistic回归分析显示：肿瘤临床分期(III、IV)、P53阳性以及ATRX阳性是NB患儿预后不良的危险因素(P<0.05)，而危险程度、Shimada病理分类不是NB患儿预后不良的危险因素(P>0.05)。结论：NB患儿P53、ATRX蛋白表达与患儿临床病理特征关系密切，是患儿预后不良的危险因素，可用于评估患儿预后。
关键词： P53；ATRX蛋白；小儿神经母细胞瘤；预后价值

Prognostic value of P53 and ATRX protein expression in children with neuroblastoma

Authors: 1LU Jieting, 2FU Cejun, 1ZHANG Jing
1 Children's General Surgery Oncology Department, Hainan Women and Children’s Medical Center, Haikou 570311, China
2 Department of Pediatric Surgery, Hainan Provincial People’s Hospital, Haikou 570311, China

CorrespondingAuthor: ZHANG Jing Email: guaren_luo1@sina.com

DOI: 10.3978/j.issn.2095-6959.2022.10.004

Foundation: This work was supported by the Hainan Province Health Industry Research Project (20A200259) and Hainan Provincial Clinical Medical Center Construction Project, China.

Abstract

Objective: To explore the prognostic value of P53 and alpha-thalassemia/mental retardation syndrome X-linked (ATRX) gene protein expression in children with neuroblastoma (NB). Methods: A total of 68 children with NB (study group) and 33 children with hydronephrosis (control group) who were admitted to Hainan Women and Children’s Medical Center from July 2018 to July 2020 were selected as the research subjects. Immunohistochemistry was used to determine the expressions of P53 and ATRX proteins in lesion tissues of the children. The various data of the children in the study group were collected, and the relationship between the expressions of P53 and ATRX proteins and the data were analyzed. Follow-up was conducted to evaluate the prognosis of children with NB. The relationship between the expressions of P53 and ATRX proteins and the prognosis of children with NB were analyzed. Results: The positive expression rates of P53 and ATRX in the study group were significantly higher than those in the control group (both P<0.05). The positive expressions of P53 and ATRX were related to the clinical stage, risk level, Shimada pathological classification, bone marrow infiltration, focal pathological diagnosis, and differentiation degree (P<0.05). Multivariate logistic regression analysis showed that clinical stage of tumor (III and IV), P53 positive expression, and ATRX positive expression were the risk factors for poor prognosis of children with NB (P<0.05). The risk level and Shimada pathological classification were not risk factors (P>0.05). Conclusion: The expressions of P53 and ATRX proteins in children with NB are closely related to the children’s clinicopathological characteristics. The two are risk factors for poor prognosis of children, and can be used to assess the prognosis.

Keywords： P53; ATRX protein; neuroblastoma in children; prognostic value

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