三阴性乳腺癌分子靶标的研究进展
| 作者: |
1罗佳娣,
1范松青
1 中南大学湘雅二医院病理科，长沙 410011 |
| 通讯: |
范松青
Email: fansongqing2003@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.06.039 |
| 基金: | 国家自然科学基金, 81272566 |
摘要
三阴性乳腺癌对激素和HER-2靶向治疗均无应答，已成为乳腺癌临床治疗的一大挑战，迫切需要 寻找对其治疗有效应答的新的分子靶标。本文综述三阴性乳腺癌分子靶标及其靶向治疗的最新研 究进展。
关键词：
分子标志物
靶向治疗
三阴性乳腺癌
Research progress in molecular targets of triple-negative breast cancer
CorrespondingAuthor: FAN Songqing Email: fansongqing2003@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2014.06.039
Abstract
Triple-negative breast cancer (TNBC) without estrogen receptor, progestrogen receptor and HER-2 expression, represents a challenge clinically due to a lack of response to hormonal and HER2-targeted agents. Therefore biomarkers predictive of response to treatment are of great importance in TNBC. This review evaluates biomarkers predictive of response to neoadjuvant chemotherapy and targeted therapies in TNBC, in order to increase opportunities to improve patient outcomes.