Objective: To investigate the current sleeping situation and differences in sleep quality between the hospitalized children aged 2–12 years old who were infected with familial aggregation Omicron variants under a parent-child ward treatment mode and the children at home during the epidemic period. Methods: From April 15, 2022 to May 14, 2022, 67 hospitalized children were selected in the Pediatric Inpatient Department of Lingang District Designated Hospital of Shanghai Sixth People’s Hospital as a positive group, and 92 children at home were selected as a control group. The sleep duration, sleep problems, and sleep status differences between the 2 groups were compared and analyzed with the Children’s Sleep Habits Questionnaire (CSHQ). Results: The bedtime of the early childhood children in the positive group was later than that in the control group, while the preschool-aged children were earlier than that in the control group; the morning wake-up time in the positive group was earlier than that in the control group from all ages; the nighttime sleep duration of early childhood children in positive group was less than that in the control group (P<0.05). The total rate of bedtime after 22:00 in the positive group from all ages was 35.82%, which was higher than that in the control group (P<0.05). The total score of CSHQ sleep problems in the positive group was higher than the critical score (>41) and higher than that in the control group, and the bedtime habit score was higher than the critical score (10.84), and the sleep duration problem score was higher than that in the control group (P<0.05). The positive rate of sleep latency and sleep duration in the positive group was 22.38% and 26.86%, respectively, which were higher than those in the control group (both P<0.05), and the incidence rate of sleep-disordered breathing and daytime hypersomnia was 14.93% and 11.94%, which were lower than those in the control group (both P>0.05). There was no statistically significant difference in the total score of CSHQ sleep problems and the scores of each sub-item in the positive group between males and females (all P>0.05); and there were statistically significant differences in the score of sleep problems such as the bedtime habits, sleep latency, sleep anxiety, night awakenings, and parasomnia in the positive group which was divided into 3 parts according to the age of the children (all P<0.05). Conclusion: Omicron infection caused changes in the sleep time of hospitalized children and increased the positive incidence rate of sleep problems. Besides, the positive phenomenon of sleep problems could be found in different ages. However, the parent-child ward mode could minimize the effects mentioned, which revealed that the parent-child ward mode should be practiced timely to promote the physical and mental health of the affected children.