Objective: To investigate the clinical efficacy of Chaihu plus Longgu Muli Decoction on menopausal-like syndrome after breast cancer treatment. Methods: According to the random control method, they were divided into a control group and a treatment group, 62 cases in each group. The control group was given oryzanol combined with vitamin B6 tablets, and the treatment group was given Chaihu plus Longgu Muli decoction. After the treatment, the clinical efficacy of the 2 groups was observed. Results: The Kupperman score, traditional Chinese medicine symptom score, Karnofsky performance status (KPS) score, and Functional Assessment of Cancer Therapy-Breast (FACT-B) score in the treatment group were better than those in the control group, and the difference was statistically significant (all P<0.05). There was no significant difference in serum sex hormone levels between the 2 groups before and after the treatment (P>0.05). Conclusion: Chaihu plus Longgu Muli Decoction can significantly improve the menopausal-like syndrome after endocrine therapy for breast cancer and has no effect on sex hormone levels. The curative effect is reliable and worthy of clinical promotion.