文章摘要

PI3K/AKT信号通路与缺血性脑损伤引起的细胞凋亡研究进展

作者: 1张家伟, 2许莉莉, 3,4吕佩源
1 河北医科大学研究生院，石家庄 050017
2 河北北方学院研究生院，河北 张家口 075000
3 河北省人民医院神经内科，石家庄 050051
4 河北省脑网络及认知障碍疾病重点实验室，石家庄 050051
通讯: 吕佩源 Email: peiyuanlu@163.com
DOI: 10.3978/j.issn.2095-6959.2022.11.034
基金: 河北省高端人才资助项目(6833452，83587216)；河北省政府资助临床医学优秀人才培养项目(2019-139-5)；河北省引智项目(2020-19-2)。

摘要

PI3K/AKT信号通路是细胞内调控信号转导的一个重要途径，其组成较为复杂，参与细胞增殖、凋亡、代谢等活动。缺血性脑损伤是一个复杂的病理过程，而细胞凋亡在此过程中发挥重要作用。PI3K/AKT信号通路是细胞存活的关键通路，在缺血性脑损伤、神经退行性疾病及肿瘤等诸多疾病中起调控作用。因此，研究该通路并探讨其在缺血性脑损伤中的作用对进一步探寻此类疾病的治疗具有重要意义。
关键词： PI3K/AKT信号通路；缺血性脑损伤；细胞凋亡

Research progress regarding PI3K/AKT signaling pathway and apoptosis induced by ischemic brain injury

Authors: 1ZHANG Jiawei, 2XU Lili, 3,4LÜ Peiyuan
1 Graduate School of Hebei Medical University, Shijiazhuang 050017, China
2 Graduate School of Hebei North University, Zhangjiakou Hebei 075000, China
3 Department of Neurology, Hebei General Hospital, Shijiazhuang 050051, China
4 Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China

CorrespondingAuthor: LÜ Peiyuan Email: peiyuanlu@163.com

DOI: 10.3978/j.issn.2095-6959.2022.11.034

Foundation: This work was supported by the Hebei Provincial High-End Talents Funding Project (6833452, 83587216), Hebei Provincial Government Funded Clinical Talents Training Project (2019-139-5), and Project of Introducing Talents to Hebei Province (2020-19-2), China.

Abstract

The PI3K/AKT signaling pathway is an important intracellular pathway to regulate signal transduction. Its composition is relatively complex, involving in cell proliferation, apoptosis, metabolism and other biological processes. Ischemic brain injury is a complex pathological process, in which apoptosis plays an important role. The PI3K/AKT signaling pathway are crucial in many human diseases including ischemic brain injury, neurodegenerative diseases, and tumors for cell survival. Therefore, the study of this pathway and its role in ischemic brain injury is of great significance to further explore the treatment of the disease.

Keywords： PI3K/AKT signaling pathway; ischemic brain injury; apoptosis

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