文章摘要

三甲胺N-氧化物与心血管疾病的研究进展

作者: 1刘冬雪, 1洪思婷, 1梁兆光
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001
通讯: 梁兆光 Email: guomengyue1988@gmail.com
DOI: 10.3978/j.issn.2095-6959.2022.11.033
基金: 国家自然科学基金(82000297)。

摘要

肠道菌群是由人类的数万亿个微生物细胞在肠道中形成的一个复杂的微生物群落。目前已有研究表明，肠道菌群与心血管疾病(cardiovascular disease，CVD)密切相关。此外，肠道微生物的代谢产物三甲胺N-氧化物(trimethylamine N-oxide，TMAO)已被广泛证明可增加高血压、冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease，CHD)、心力衰竭(heart failure，HF)和心房颤动(atrial fibrillation，AF)的风险。
关键词： 三甲胺N-氧化物；肠道菌群；心血管疾病

Research progress of trimethylamine N-oxide and cardiovascular disease

Authors: 1LIU Dongxue, 1HONG Siting, 1LIANG Zhaoguang
1 Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: LIANG Zhaoguang Email: guomengyue1988@gmail.com

DOI: 10.3978/j.issn.2095-6959.2022.11.033

Foundation: This work was supported by the National Natural Science Foundation, China (82000297).

Abstract

The intestinal flora is a complex microbial community formed by trillions of human microbial cells in the gastrointestinal tract. Nowadays, it has been reported that the intestinal flora is closely related to cardiovascular disease (CVD). Moreover, trimethylamine N-oxide (TMAO), a metabolite derived from intestinal microorganisms, has been widely shown to augment the risk of developing hypertension, coronary atherosclerotic heart disease (CHD), heart failure (HF), and atrial fibrillation (AF).

Keywords： trimethylamine N-oxide; intestinal flora; cardiovascular disease

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