Objective: To investigate the effect of air pressure wave combined with conventional measures on deep vein thrombosis (DVT) in patients with benign gynecologic tumors after laparoscopic surgery. Methods: A total of 200 patients with benign gynecological tumors scheduled for laparoscopic surgery in our hospital from January 2019 to December 2021 were selected and randomly divided into 2 groups, each group with 100 cases. The control group was treated with low molecular weight heparin and graduated compression stockings. The observation group was treated with air pressure wave on the basis of the control group. The general situation, coagulation function, femoral vein blood flow velocity and DVT incidence were compared between the 2 groups. Results: There was no significant difference in postoperative ambulation time and drainage tube indwelling time between the 2 groups (P>0.05), the hospitalization time of the observation group was significantly shorter than that of the control group (P<0.05). At 1 day after operation, there was no significant difference in coagulation function indexes [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), and D-dimer (D-D)] between the 2 groups (all P>0.05). At 3 days after operation, the PT, APTT, and TT in the observation group were significantly longer than those in the control group (all P<0.05), and FIB and D-D levels were significantly lower than those in the control group (P<0.05). At 3, 5, and 7 d after operation, the blood flow velocity of left femoral vein and right femoral vein in the observation group were significantly higher than those in the control group (P<0.05). The incidence of DVT within 7 d after operation in the observation group was 5.00%, which was significantly lower than 13.00% in the control group (P<0.05). Conclusion: Air pressure wave combined with conventional measures can effectively prevent DVT of Lower Extremity in patients with benign gynecological tumor after laparoscopic surgery.