Objectives: To discuss and analyze the occurrence of pressure sores on noses and faces of patients with non-invasive positive pressure ventilation (NPPV) and the related risk factors, and to provide effective references for working out targeted preventive and nursing intervention. Methods: A 1∶1 case–control research method was adopted. General demographic characteristics, general nutrition and illness conditions, NPPV use conditions and occurrence of pressure sores on noses and faces, etc. were collected via looking up the electronic medical records and nursing records. Logistic regression analysis was adopted to analyze and discuss the risk factors of pressure sores on noses and faces of patients with continuous NPPV. Results: Forty-eight out of 173 NPPV patients had pressure sores on noses and faces (27.7%); specifically, 17 patients had 1st-stage pressure sores (9.8%), 30 patients had 2nd-stage pressure sores (17.3%) and 1 patient had 3rd-stage pressure sores (0.6%). As indicated by the Logistic regression analysis results, the influence factors for pressure sores on noses and faces of the patients with continuous NPPV were as follows: age, Glasgow score, SAS score, serum albumin amount, PaO2 level, face edema, NPPV usage method, total NPPV usage time, usage of pressure reduction protective pastes, diabetes hypotension, usage of steroid medicines and usage of cardiovascular activity medicines. Conclusion: Pressure sore on noses and faces is a common complication among patients with continuous NPPV. The clinical nurses can conduct preventive nursing, according to the specific conditions of the patients and related influence factors, to avoid the occurrence of pressure sores on nose and face.