文章摘要

原发部位不明的转移性神经内分泌瘤伴直肠腺癌1例

作者: 1朱庆, 2高宠, 1卜雯婧, 1张红凯
1 首都医科大学附属北京中医医院病理科，北京 100010
2 首都医科大学附属北京中医医院血液科，北京 100010
通讯: 张红凯 Email: zhk0484@sina.com
DOI: 10.3978/j.issn.2095-6959.2022.11.039

摘要

神经内分泌肿瘤(neuroendocrine neoplasm，NEN)伴结直肠腺癌十分罕见，对患者的临床病理诊断及治疗都构成了一定挑战。本文报道了1例58岁男性因便血就诊，临床及辅助检查提示直肠癌伴肝转移，经新辅助化疗后行直肠肿瘤切除，术后病理诊断为直肠中分化腺癌伴原发部位不明的转移性神经内分泌瘤(neuroendocrine tumor，NET)G1，伴腺癌及NET淋巴结转移。通过相关临床病理分析认为此类病例容易漏诊，需要对相关脏器进行更彻底的评估，其治疗及预后通常由更具侵袭性的肿瘤决定。
关键词： 神经内分泌肿瘤；腺癌；结直肠；转移；临床病理

A case of metastatic neuroendocrine tumor of unknown primary site with rectal adenocarcinoma

Authors: 1ZHU Qing, 2GAO Chong, 1BU Wenjing, 1ZHANG Hongkai
1 Department of Pathology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
2 Department of Hematology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

CorrespondingAuthor: ZHANG Hongkai Email: zhk0484@sina.com

DOI: 10.3978/j.issn.2095-6959.2022.11.039

Abstract

Neuroendocrine neoplasm (NEN) with colorectal adenocarcinoma is rare and represents a challenge for clinicopathological diagnosis and management of patients. We reported a 58-year-old male patient with hematochezia. Clinical and adjuvant examination suggested rectal cancer with liver metastasis. He underwent rectal tumor resection after neoadjuvant chemotherapy. The final pathology diagnosis was moderately differentiated adenocarcinoma of the rectum with a metastatic neuroendocrine tumor (NET) of unknown primary site G1, with adenocarcinoma and NET metastasis in lymph nodes. Clinicopathological analysis reveals such cases are considered to be easily missed and require a more thorough evaluation of the involved organs, whose treatment and prognosis are usually determined by more aggressive tumors.

Keywords： neuroendocrine neoplasm; adenocarcinoma; colorectal; metastasis; clinical pathology

文章选项

下载引文

分享