慢性阻塞性肺疾病的骨骼肌功能障碍与FOXO
| 作者: |
1邓佳音,
1胡瑞成
1 南华大学附属省马王堆医院/湖南省老年医院呼吸疾病研究所，长沙 410016 |
| 通讯: |
胡瑞成
Email: huruicheng@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.04.035 |
| 基金: | 国家自然科学基金, 81070035 |
摘要
骨骼肌功能障碍是慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)的重要组成部分，它包括呼吸肌以及外周非呼吸肌的功能下降，具体表现为：肌肉体积减小，运动强度下降，运动耐力下降。骨骼肌功能障碍严重影响到COPD患者的生活质量及疾病的预后。但是目前COPD的骨骼肌功能障碍发生的具体机制尚不十分明确。研究证实叉形头转录蛋白因子-O(fork head transcription factor protein O，FOXO)在维持骨骼肌的功能中具有重要作用。现就COPD患者的骨骼肌障碍与FOXO的关系进行综述。
关键词：
慢性阻塞性肺疾病
骨骼肌功能障碍
FOXO
泛素蛋白酶体
Muscle dysfunction in chronic obstructive pulmonary disease and FOXO
CorrespondingAuthor: HU Ruicheng Email: huruicheng@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2016.04.035
Abstract
Skeletal muscle dysfunction, including respiratory muscle and peripheral muscle function decline, is an important part of chronic obstructive pulmonary disease (COPD). The function decline mainly manifested as decreased volume, lower exercise intensity and reduced endurance. It seriously affects the patient’s quality of life and prognosis of the disease. But the mechanisms of skeletal muscle dysfunction in COPD are unclear at present. Study confirmed the fork head transcription factor protein O (FOXO) plays an important role in the function maintenance of the skeletal muscle. Below to the relationship of skeletal muscle dysfunction in COPD patients and FOXO were reviewed.