Objective: To explore the effect of nursing mode based on Noddings’ care theory on comfort, compliance, and quality of life of children with mycoplasma pneumonia treated by aerosol inhalation. Methods: From December 2019 to November 2021, 120 children with mycoplasma pneumonia who were treated by aerosol inhalation in the Department of Pediatrics, Fuyang Women and Children Hospital were selected as subjects. According to the random number table method, patients were randomly divided into a control group (n=60) and an observation group (n=60). The control group was given routine nursing mode, and the observation group was given nursing mode based on Nodding’ caring theory on the basis of the control group. The comfort degree of aerosol inhalation therapy [Face, Legs, Activity, Cry, Consolability (FLACC) scale], compliance of aerosol inhalation therapy, symptom relief time, quality of life [the Pediatric Quality of Life Inventory Measurement Models (PedsQL) 4.0], and parental satisfaction were compared between the 2 groups. Results: Scores of facial expression, leg activity, posture, crying, soothing, and total score of FLACC in the observation group were lower than those in the control group (all P<0.05). The rate of atomization inhalation compliance in the observation group was 94.83%, which was higher than that of the control group of 82.60% (P<0.05). The duration of symptoms and hospitalization time in the observation group were shorter than those in the control group (both P<0.05). At discharge, the scores of subscales and total score of PedsQL 4.0 in the observation group were higher than those in the control group (all P<0.05). The total satisfaction rate of parents in the observation group was higher than that in the control group (P<0.05). Conclusion: The nursing mode based on the Noddings’ care theory can promote the atomization inhalation comfort of children with mycoplasma pneumonia, thereby improving their treatment compliance, shortening the duration of symptoms, and improving their therapeutic effect and quality of life.