Objective: To explore the effect of solution-focused short-course psychological intervention on negative emotions, subjective well-being, and quality of life of patients with cataract surgery. Methods: A total of 98 patients with cataract who underwent surgical treatment in General Hospital of Wanbei Coal and Electricity Group from January 2021 to December 2021 were selected as research objects. Patients were divided into a control group and an observation group according to random number table method, with 49 cases in each group. The control group was given routine psychological intervention, and the observation group was given a focus solution on a short-term psychological intervention based on the control group. The changes of mental state [Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Positive and Negative Emotion Scale], coping style [Simple Coping Style Questionnaire], subjective well-being [General Well-Being Schedule (GWBS)], and quality of life score at admission and discharge were compared between the 2 groups. Results: At discharge, the SDS, SAS scores, negative factor scores, and negative coping style subscale scores of the observation group were significantly lower than those of the control group (all P<0.05), and the positive factor scores and positive coping style scores of the observation group were significantly higher than those of the control group (P<0.05). At discharge, the GWBS score and quality of life score in the observation group were significantly higher than those in the control group (both P<0.05). Conclusion: Solution-focused short-course psychological intervention for cataract patients can significantly reduce their anxiety and depression, and improve their subjective well-being and quality of life.