文章摘要

肝内胆管癌的诊治进展

作者: 1,2王杰, 1张洪新, 1袁鹏, 1胡龙泉
1 空军军医大学第二附属医院介入疼痛科,西安 710038
2 空军军医大学基础医学院,西安 710032
通讯: 袁鹏 Email: yuanpeng834700@126.com
胡龙泉 Email: 616879635@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.10.036
基金: 国家自然科学基金(81802345,82172922);中国博士后科学基金(2020T130787,2019M663984);空军军医大学第二附属医院国家自然科学基金助推项目计划(2021ZTXM-002)。

摘要

肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)是发生在二级及以上胆管分支上皮细胞的恶性肿瘤,该疾病预后较差且近年来发病率持续升高。目前已知的常见危险因素包括慢性肝炎、肝硬化、胆道炎性疾病和肝胆吸虫,症状表现为腹部隐痛和其他非特异症状。ICC是一种高侵袭性恶性肿瘤,根治性手术切除是首选治疗方式。近年来,在ICC的诊断和治疗方面取得了一些进展,肿瘤分期方法不断更新,晚期和转移性肿瘤患者也可应用辅助化疗、靶向治疗和免疫治疗。
关键词: 肝内胆管癌;诊断;治疗

Progress in diagnosis and treatment of intrahepatic cholangiocarcinoma

Authors: 1,2WANG Jie, 1ZHANG Hongxin, 1YUAN Peng, 1HU Longquan
1 Department of Intervention and Pain, Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China
2 Basic Medical College, Air Force Medical University, Xi’an 710032, China

CorrespondingAuthor: YUAN Peng Email: yuanpeng834700@126.com

DOI: 10.3978/j.issn.2095-6959.2022.10.036

Foundation: This work was supported by the National Natural Science Foundation (81802345, 82172922), China Postdoctoral Science Foundation (2020T130787, 2019m663984), and the National Natural Science Foundation, Second Affiliated Hospital of Air Force Military Medical University (2021ZTXM-002), China.

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that occurs proximal to the segmental biliary ducts, The prognosis of this disease is poor, and the incidence of this disease has continued to increase in recent years. Commonly known risk factors include chronic hepatitis, cirrhosis, biliary inflammatory disease, and hepatobiliary fluke, which are characterized by dull abdominal pain and other nonspecific symptoms. ICC is a highly aggressive malignant tumor, and radical surgical resection is the preferred treatment. In recent years, some progress has been made in the diagnosis and treatment of ICC. Tumor staging methods are constantly updated, and adjuvant chemotherapy, targeted therapy and immunotherapy can also be applied to patients with advanced and metastatic tumors.

Keywords: intrahepatic cholangiocarcinoma; diagnosis; treatment

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