病理在肺癌治疗中的关键角色
作者: |
1,2Morgan R. Davidson,
3,4Adi F. Gazdar,
1,5Belinda E. Clarke
1 University of Queensland Thoracic Research Centre, The Prince Charles Hospital, QLD, Australia 2 Department of Anatomical Pathology, Royal Brisbane and Women’s Hospital, QLD, Australia 3 The Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA 4 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA 5 Department of Anatomical Pathology, The Prince Charles Hospital, QLD, Australia |
通讯: |
Morgan R. Davidson
Email: morgan.davidson@uqconnect.edu.au |
DOI: | 10.3978/j.issn.2095-6959.2015.07.012 |
摘要
在过去的十年中,我们对于肺癌生物学和治疗的认识取得了显著进步。识别肺癌发生的关键驱动事件对其靶向治疗的发展作出了贡献,预示着肺癌的个性化医疗时代的到来。因此,病理分型和分子检测变得至关重要,而日益增加的检测需求往往是基于小的诊断标本。这使得国际肺癌研究学会/美国胸科学会/欧洲呼吸学会[The International association for the study of cancer(IASLC)/American thoracic society (ATS)/European respiratory society (ERS)]对小活检/细胞学肺癌标本的第一次结构分类进行了审视和推动,并且提出了肺腺癌的新分类。这些都提高了病理诊断的临床相关性,强调了现代外科病理学家作为多学科团队中成员的作用,在肺癌患者的临床试验和确定适当和及时的治疗中发挥了决定性作用。
关键词:
肺肿瘤
病理学
非小细胞肺癌(non-small cell lung cancer,NSCLC)
小细胞肺癌(small cell lung cancer,SCLC)
The pivotal role of pathology in the management of lung cancer
DOI: 10.3978/j.issn.2095-6959.2015.07.012