文章摘要

髓源性抑制细胞在骨转移中的作用及治疗进展

作者: 1王聪, 1俞静
1 首都医科大学附属北京友谊医院肿瘤科，北京 100050
通讯: 俞静 Email: yujing026@ccmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2022.10.033
基金: 国家自然科学基金(81774221)；北京市自然科学基金(7212168)。

摘要

髓源性抑制细胞(myeloid-derived suppressor cells，MDSCs)是一种具有免疫抑制功能的未成熟髓样细胞(immature myeloid cells，IMCs)，对肿瘤的生长和转移至关重要。MDSCs通过抑制T细胞增殖、抗肿瘤活性及促进调节性T细胞的增殖而发挥其免疫抑制功能。此外，MDSCs还能在骨微环境中通过与破骨细胞、成骨细胞及骨基质细胞等相互作用，促进肿瘤骨转移。因此针对MDSCs的治疗可能为未来改善恶性肿瘤骨转移的预后提供新的药物靶点。
关键词： 髓源性抑制细胞；骨转移；骨微环境；破骨细胞

Advances of role and treatment of myeloid-derived suppressor cells in bone metastases

Authors: 1WANG Cong, 1YU Jing
1 Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

CorrespondingAuthor: YU Jing Email: yujing026@ccmu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2022.10.033

Foundation: This work was supported by the National Natural Science Foundation (81774221) and Beijing Natural Science Foundation (7212168), China.

Abstract

Myeloid-derived suppressor cells (MDSCs), which are essential for tumor growth and metastasis, are immature myeloid cells (IMCs) with immunosuppressive functions. By inhibiting proliferation and antitumor activities of T cells and promoting the proliferation of regulatory T cells, MDSCs can serve their immunosuppressive functions. MDSCs in the bone-metastasis microenvironment interact with osteoclasts and stromal cells, leading to an acceleration of cancer-related bone metastasis. Therefore, the treatment of MDSCs may provide new drug targets for improving the prognosis of bone metastases of malignant tumors in the future.

Keywords： myeloid-derived suppressor cells; bone metastasis; bone microenvironment; osteoclast

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