Objective: To study the efficacy of silver ion gel combined with scab cutting and skin grafting and vacuum sealing drainage (VSD) on deep burn wound and its effect on inflammatory factors and pain-causing factors. Methods: A total of 100 patients with deep burn wounds admitted to our hospital from January 2020 to January 2022 were selected and randomly divided into an observation group and a control group, with 50 patients in each group. Patients in both groups were treated with scab cutting and skin grafting, the control group was treated with VSD technology after scab cutting and skin grafting, and the observation group was treated with silver ion gel based on the control group, both groups continued treatment until wound healing. The recovery situation, the changes of the C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), and neuropeptide Y (NPY) before the treatment and 2 weeks after the treatment and the incidence of complications of 2 groups were compared. Results: The granulation growth time, wound healing, and hospitalization in the observation group were shorter than that of the control group, the difference were statistically significant (all P<0.05); the CRP, TNF-α, IL-6, 5-HT, PGE2, and NPY levels in observation group were lower than those of the control group, the difference were statistically significant (all P<0.05); the total incidence of complications in the observation group was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: Silver ion gel combined with scab cutting and skin grafting and VSD has a significant effect on the treatment of deep burn wounds, which can actively promote wound recovery and reduce the expression of inflammatory factors and pain-causing factors, which is worthy of clinical promotion.