Objective: To explore the effect of low-frequency electrical stimulation combined with Motomed exercise training on patients with neurogenic bladder caused by spinal cord injury. Methods: A total of 96 patients with neurogenic bladder caused by spinal cord injury in Wuxi Mental Health Center from January 2019 to January 2022 were randomly divided into 2 groups with 48 cases in each group. The control group was treated with low-frequency electrical stimulation, and the observation group implemented Motomed exercise training on the basis of the control group. The clinical efficacy, urination, urodynamics, symptom improvement, and the incidence of complications were compared between the 2 groups. Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05); the daily urination volume, maximum daily urination volume, and average daily urination frequency after 2 months of intervention in the observation group were more than those in the control group (all P<0.05). The residual urine volume of the observation group after 2 months of intervention was less than that of the control group, and the maximum urine flow rate, intravesical pressure, and bladder volume were higher than those of the control group (all P<0.05). Lower urinary tract symptom (LUTS) and Urinary Symptom Distress Scale (USDS) scores of the observation group were lower than those of the control group after 2 months of intervention (both P<0.05); the total complication rate in the observation group was lower than that in the control group (P<0.05). Conclusion: Low-frequency electrical stimulation combined with Motomed exercise training in patients with neurogenic bladder caused by spinal cord injury can improve the efficacy, improve urination and urodynamic indicators, reduce clinical symptoms, and reduce the incidence of complications.