文章摘要

有氧运动疗法联合选择性5-羟色胺再摄取抑制剂对青少年抑郁症患者精神症状缓解效果和社会功能的影响

作者: 1符泽娟, 1徐明雅, 1王天道, 1陈雪虹, 1王爱花
1 海南省安宁医院医学心理科，海南 安宁 570206
通讯: 符泽娟 Email: 1280753707@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.12.028

摘要

目的：探究有氧运动疗法联合选择性5-羟色胺再摄取抑制剂(selective 5-hydroxytryptamine reuptake inhibitors，SSRIs)对青少年抑郁症患者精神症状缓解效果和社会功能的影响。方法：选取2020年1月至2021年12月海南省安宁医院收治的90例青少年抑郁症患者为研究对象，按随机数字表法将其随机分为对照组与观察组，每组45例。对照组予以SSRIs治疗，观察组在SSRIs治疗基础上增加有氧运动。比较两组临床疗效，治疗前后汉密尔顿抑郁量表(Hamilton Depression Scale，HAMD-24)评分、个体和社会功能量表(Personaland Social Performancescale，PSP)评分、情绪智力量表(Emotional Intelligence Scale，EIS)评分、认知功能[连线测验-A部分(Trail Making Test-A，TMT-A)用时、数字广度-倒背测验(Digit Span-Sequential Order，DS-RO)评分、连线测验-B部分(Trail Making Test-B，TMT-B)用时]，血浆5-羟色胺(5-hydroxtryptamine，5-HT)、血清白细胞介素-6(interleukin-6，IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)、脑源性神经营养因子(brain-derived neurotrophic factor，BDNF)、胶质源性神经营养因子(glial cell line-derived neurotrophic factor，GDNF)水平。结果：观察组临床总有效率明显高于对照组(93.33% vs 77.78%，P<0.05)。观察组治疗后HAMD-24评分明显低于对照组，PSP、EIS评分则明显更高(均P<0.05)。与对照组相比，观察组治疗后的TMT-A、TMT-B用时更短，DS-RO评分更高(均P<0.05)。观察组治疗后血清BDNF、GDNF及血浆5-HT水平均明显高于对照组，血清IL-6、TNF-α水平则更低(均P<0.05)。结论：有氧运动疗法联合SSRIs可有效缓解青少年抑郁症患者精神症状，改善其社会功能、认知功能，提高5-HT及神经营养因子水平、抑制炎症反应可能是其发挥疗效的机制。
关键词： 有氧运动；选择性5-羟色胺再摄取抑制剂；抑郁症；精神症状；社会功能；青少年

Effects of aerobic exercise therapy combined with selective 5-hydroxytryptamine reuptake inhibitor on the remission of psychiatric symptoms and social function in adolescent patients with depression

Authors: 1FU Zejuan, 1XU Mingya, 1WANG Tiandao, 1CHEN Xuehong, 1WANG Aihua
1 Department of Medical Psychology, Hainan Anning Hospital, Anning Hainan 570206, China

CorrespondingAuthor: FU Zejuan Email: 1280753707@qq.com

DOI: 10.3978/j.issn.2095-6959.2022.12.028

Abstract

Objective: To explore the effect of aerobic exercise therapy combined with selective 5-hydroxytryptamine reuptake inhibitors (SSRIs) on the remission effect of psychiatric symptoms and social function in adolescent patients with depression. Methods: A total of 90 patients with adolescent depression admitted to Hainan Anning Hospital from January 2020 to December 2021 were randomly divided into a control group and an observation group, with 45 cases in each group. The control group was treated with SSRIs, and the observation group was treated with aerobic exercise based on SSRIs. The clinical efficacy of the 2 groups was compared, including Hamilton Depression Scale (HAMD-24) score, Personaland Social Performance Scale (PSP) score, Emotional Intelligence Scale (EIS) score, cognitive function [time of Trail Making Test-A (TMT-A), Digit Span-Sequential Order (DS-RO) score, time of Trail Making Test-B (TMT-B)], 5-hydroxtryptamine (5-HT), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) levels before and after the treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group (93.33% vs 77.78%, P<0.05). After the treatment, HAMD-24 scores in the observation group were significantly lower than those in the control group, PSP and EIS scores were significantly higher (all P<0.05). Compared with the control group, the time of TMT-A and TMT-B in the observation group after the treatment was shorter, and the DS-RO score was higher (all P<0.05). After the treatment, the serum BDNF, GDNF, and the plasma 5-HT level in the observation group was significantly higher than that in the control group, and the serum IL-6 and TNF-α levels were lower (all P<0.05). Conclusion: Aerobic exercise therapy combined with SSRIs can effectively alleviate the mental symptoms of adolescent patients with depression, improve their social function and cognitive function, increase the level of 5-HT and neurotrophic factors, inhibitthe inflammatory response, which may be the mechanism for its efficacy.

Keywords： aerobic exercise; selective serotonin reuptake inhibitor; depression; mental symptoms; social function; teenagers

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