Objective: To investigate the effect of simultaneous repair on unilateral complete cleft lip nasolabial deformity and its influencing factors. Methods: Thirty children with unilateral complete cleft lip and nasolabial deformity were selected, and the modified Millard II method was used to repair the cleft lip, and the nasal deformity was repaired at the same time. Lip height, lip peak Angle distance, columella height, and nasal base width were measured before and after the operation, and the postoperative efficacy was evaluated. Results: The nasolabial deformities of 30 children were improved to varying degrees. After 12 months of follow-up, 16 cases (53.33%) had obvious curative effect, and 14 cases (46.67%) had no obvious curative effect. The total incidence of postoperative complications was only 13.33%. After the treatment, the height of the lip, the columella on the affected side, the distance between the lip crest, and the mouth angle and the width of the nasal floor were significantly increased. Further analysis found that the history of maxillary dysplasia was an influencing factor for the postoperative curative effect of children. Conclusion: The initial simultaneous repair of unilateral complete cleft lip nasolabial deformity can achieve satisfactory short-term results, with low complication rate and high clinical application value.