中国人群肝脂酶基因250G/A多态性与肝细胞癌发生风险的关系
| 作者: |
1李美梁,
1李艳春,
1赵鸿皓,
1胡庆
1 湖南省人民医院病理科，长沙 410005 |
| 通讯: |
李艳春
Email: 1425649618@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.09.029 |
摘要
目的：探讨中国人群中肝脂酶基因250G/A位点多态性与肝细胞癌(以下简称肝癌)发病风险的相关性。方法：采用PCR-RFLP技术检测、计算286例肝癌患者和198例健康者肝脂酶基因250G/A位点基因型频率分布情况，并利用logistic回归分析各危险因素与肝癌发生风险的关系。结果：GA和AA基因型频率均存在显著组间差异(均P<0.05)，携带GA、AA基因型的个体罹患肝癌的风险显著高于GG基因型。Logistic回归分析结果表明肝脂酶基因250G/A位点GA+AA基因型为肝细胞癌发生的危险因素。结论：携带突变基因A等位基因可能会增加肝癌的发病风险。
关键词：
肝脂酶
250G/A位点
肝细胞癌
基因多态性
The relationship between the hepatic lipase gene 250G/A polymorphism and the risk of hepatocellular carcinoma in Chinese population
CorrespondingAuthor: LI Yanchun Email: 1425649618@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.09.029
Abstract
Objective: To investigate the relationship between the hepatic lipase (HL) gene 250G/A polymorphism and the risk of hepatocellular carcinoma (HCC) in Chinese population. Methods: The PCR-RFLP was applied for detecting and calculating the distribution of HL gene 250G/A polymorphism of 286 HCC patients and 198 healthy people. Logistic regression analysis was used for investigating the relationship between the risk factors and risk of HCC. Results: A significant difference was found in comparisons of GA and AA genotype frequencies between two groups (both P<0.05). The risk of HCC was significantly higher in individuals with AA and GA genotype than in GG genotype. Logistic regression analysis showed that the GA+AA genotype of 250G/A polymorphism was a risk factor of HCC. Conclusion: Patients carrying the mutant gene A allele (rs2070895) may increase the risk of HCC.