Objective: Study of the effect of vacuum sealing drainage in the treatment of infection wound healing at later stage of large area burn. Methods: A retrospective analysis of 17 patients with refractory infection wounds at later stage of large area burn from September 2011 to August 2014. Debridement + blade thickness from 1 week after treatment ineffective stamp body skin transplantation or conventional dressing, using debridement and skin grafting combined with vacuum-assisted closure wound repair. Treatment of the first three days the line wound secretions bacterial culture, the concept of survival Chapi sheet, 6 days of treatment disable VAC therapy, wound healing rate was observed and recorded. After which regular dressing to the wound healed, the dressing was observed during treatment pain, and the wound is completely healed record time. Results: 3 days of debridement and skin grafting combined with vacuum sealing drainage after treatment, 4 cases of wound secretion culture of methicillin resistant staphylococcus aureuspositive, skin graft survival rate was 83.9% in average; 6 days after treatment, the wound healing rate was 85.7%. During the treatment of patients with pain relief was significantly reduced compared with the previous. A total of 17 patients were healed after 36~49 d. Conclusion: Vacuum assisted closure therapy is effective in treatment at large area burn wound infection; vacuum assisted closure therapy can significantly improve the skin graft survival rate, and promote wound healing.