Objective: To investigate the internal relationship between CT measurement of visceral fat area (VFA) and perioperative indexes in patients undergoing laparoscopic radical resection of colorectal cancer. Methods: The data of 82 patients with colorectal cancer who underwent laparoscopic radical resection in the Affiliated Hospital of West Anhui Vocational College of Health from April 2019 to August 2021 were analyzed retrospectively. All patients underwent total abdominal CT examination before operation. According to the CT measurement value of VFA, 39 patients with VFA ≥100 cm² and 43 patients with VFA <100 cm² were classified as a visceral obesity (VO) group and a visceral non-obesity (VNO) group respectively. The perioperative related indexes of the two groups were compared and analyzed. Results: The BMI of the VO group was higher than that of the VNO group, the operation time and hospital stay were longer than those of the VNO group, the incidence of anastomotic leakage and the total complication rate were higher than those of the VNO group, and the number of lymph nodes was less than that of the VNO group (all P<0.05). There was a moderate positive correlation between VFA and BMI in patients with colorectal cancer (r=0.627, P<0.05). Age (OR =2.417, 95%CI: 1.103–4.812) and VFA (OR =3.412, 95%CI: 1.326–5.976) were independent influencing factors of surgical complications in patients with colorectal cancer (P<0.05). BMI was not significantly associated with surgical complications (P>0.05). Conclusion: VFA ≥100 cm² will prolong the operation time and hospital stay of laparoscopic radical resection of colorectal cancer, increase the difficulty of lymph node detection and the risk of surgical complications.