文章摘要

奥马珠单抗治疗过敏性疾病

作者: 1杨琰茗, 1任丹阳, 2翁稚颖, 1涂彩霞, 1沈建玲, 1李云巍, 1刘艳, 1李惠英
1 昆明医科大学附属儿童医院药剂科，昆明 650000
2 昆明医科大学药学院暨云南省天然药物药理重点实验室，昆明 650000
通讯: 李惠英 Email: lihuiying@etyy.cn
DOI: 10.3978/j.issn.2095-6959.2022.07.035

摘要

过敏性疾病的发病率在全球呈现增高趋势，已被世界卫生组织列为21世纪重点防治的三大疾病之一。IgE是过敏性变态反应的重要介质，也是过敏性疾病临床治疗的重要靶点。奥马珠单抗通过靶向结合游离IgE、下调效应细胞上的IgE高亲和力受体，从而减缓或阻止IgE介导的过敏反应。奥马珠单抗的作用机制为过敏性疾病治疗工作提供了强有力的理论基础，在过敏性哮喘、过敏性鼻炎、慢性自发性荨麻疹、特异性皮炎、食物过敏等多种IgE介导的过敏性疾病中表现出了巨大的临床潜力，具有良好的应用前景及推广意义。
关键词： 奥马珠单抗；免疫球蛋白E人源单克隆抗体；过敏性疾病；疗效；安全

Omalizumab for allergic diseases

Authors: 1YANG Yanming, 1REN Danyang, 2WENG Zhiying, 1TU Caixia, 1SHEN Jianling, 1LI Yunwei, 1LIU Yan, 1LI Huiying
1 Department of Pharmacy, Children’s Hospital of Kunming Medical University, Kunming 650000, China
2 School of Medicine, Kunming Medical University and Yunnan Key Laboratory of Natural Drug Pharmacology, Kunming 650000, China

CorrespondingAuthor: LI Huiying Email: lihuiying@etyy.cn

DOI: 10.3978/j.issn.2095-6959.2022.07.035

Abstract

The incidence of allergic diseases is increasing globally and has been listed by the World Health Organization as one of the three major diseases for prevention and treatment in the 21st century. IgE is an important mediator of allergic reactions and an important target for clinical treatment of allergic diseases. Omalizumab slows or prevents IgE-mediated allergic reactions by targeting free IgE binding and down-regulating IgE high-affinity receptors on effector cells. The resistance mechanism of omalizumab in the treatment of allergic disease work provides a strong theoretical foundation, in allergic asthma, allergic rhinitis and chronic idiopathic urticaria and atopic dermatitis, food allergies and other IgE mediated show a great clinical potential in allergic disease, has a good application prospect and popularization significance.

Keywords： omalizumab; immunoglobulin E; allergic diseases; efficacy; safety

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