Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of prostatic-type epithelial polyp of the urethra. Methods: A case of prostatic-type epithelial polyp of the urethra from People’s Hospital of Wuqing was selected. We collected the clinical data, laboratory and pathological examination data, the treatment and follow-up of the patients, and analyzed the data with a literature review. Results: A 33-year-old man presented with a 2-year history of waist-abdomen. Ultrasonography of urinary tract showed right hydronephrosis and ureteral calculi. Ureteroscopic revealed a polypoid lesion (the diameter of 5 mm) located in the prostatic urethra during holmium laser lithotripsy. Microscopic sections showed acini and papillae with true fibrovascular cores lined by benign-appearing prostatic epithelium with admixed benign urothelium. Prostatic-type epithelial polyp consisted of an outer row of secretory cells and a subjacent layer of basal cells. Immunohistochemically, the cytoplasm of secretory cells were positive for PSA, and the nucleus of basal cells were positive for P63. Both of them were negative for P504s and Ki-67. Other causes of papillary lesion were excluded on the base of medical history, histopathology and other accessory examinations before the diagnosis of prostatic-type epithelial polyp. The patient had a complete remission after fragmentation and cystoscopic excision without recurrence for two years during the follow-up. Conclusion: Prostatic-type epithelial polyp of the urethra is rare and timely diagnosis is important for successful therapy. Histological differential diagnoses should include prostatic ductal adenocarcinoma presenting as a urethral polyp, etc. The final diagnosis should be based on histological examination combined with the patient history, clinical manifestation, endoscopy finding, histomorphological and immunostaining testing.